تفاصيل الوثيقة
|
نوع الوثيقة |
: |
مقال في مجلة دورية |
|
عنوان الوثيقة |
: |
A Novel four-way complex variant translocation involving chromosome 46, XY, t (4; 9; 19; 22)(q25: q34; p13. 3; q11. 2) in a chronic myeloid leukemia patient A Novel four-way complex variant translocation involving chromosome 46, XY, t (4; 9; 19; 22)(q25: q34; p13. 3; q11. 2) in a chronic myeloid leukemia patient |
|
لغة الوثيقة |
: |
الانجليزية |
|
المستخلص |
: |
Philadelphia (Ph) chromosome (9;22)(q34;q11) is well established in more than 90%
of chronic myeloid leukemia (CML) patients, and the remaining 5–8% of CML patients
show variant and complex translocations, with the involvement of third, fourth, or fifth
chromosome other than 9;22. However, in very rare cases, the fourth chromosome is
involved. Here, we found a novel case of four-way Ph+ chromosome translocation involving
46,XY,t(4;9;19;22)(q25:q34;p13.3;q11.2) with CML in the chronic phase. Complete
blood cell count of the CML patient was carried out to obtain total leukocytes count,
hemoglobin, and platelets. Fluorescence in situ hybridization technique was used for
the identification of BCR–ABL fusion gene, and cytogenetic test for the confirmation of
Ph (9;22)(q34;q11) and the mechanism of variant translocation in the bone marrow. The
patient is successfully treated with a dose of 400 mg/day imatinib mesylate (Gleevec). We
observed a significant decrease in white blood cell count of 11.7 × 109/L after 48-month
follow-up. Patient started feeling better generally. There was a reduction in the swelling
of the body, fatigue, and anxiety. |
|
ردمد |
: |
103-389 |
|
اسم الدورية |
: |
Frontiers in Oncology |
|
المجلد |
: |
6 |
|
العدد |
: |
1 |
|
سنة النشر |
: |
1437 هـ
2016 م |
|
نوع المقالة |
: |
مقالة علمية |
|
تاريخ الاضافة على الموقع |
: |
Wednesday, July 12, 2017 |
|
الباحثون
| Muhammad Asif | Asif, Muhammad | باحث | دكتوراه | |
| Mohammad Sarwar Jamal | Jamal, Mohammad Sarwar | باحث | دكتوراه | |
| Abdul Rehman Khan | Khan, Abdul Rehman | باحث | دكتوراه | |
| Muhammad Imran Naseer | Naseer, Muhammad Imran | باحث | دكتوراه | |
| Abrar Hussain | Hussain, Abrar | باحث | دكتوراه | |
| Hani Choudhry | Choudhry, Hani | باحث | دكتوراه | |
| Arif Malik | Malik, Arif | باحث | دكتوراه | |
| Shahida Aziz Khan | Khan, Shahida Aziz | باحث | دكتوراه | |
| Maged Mostafa Mahmoud | Mahmoud, Maged Mostafa | باحث | دكتوراه | |
| Ashraf Ali | Ali, Ashraf | باحث | دكتوراه | |
| Saima Iram | Iram, Saima | باحث | دكتوراه | |
| Kashif Kamran | Kamran, Kashif | باحث | دكتوراه | |
| Asim Iqbal | Iqbal, Asim | باحث | دكتوراه | |
| Zainularifeen Abduljaleel | Abduljaleel, Zainularifeen | باحث | دكتوراه | |
| Peter Natesan Pushparaj | Pushparaj, Peter Natesan | باحث | دكتوراه | |
| Mahmood Rasool | Rasool, Mahmood | باحث | دكتوراه | |
|
الرجوع إلى صفحة الأبحاث
|