|
نوع الوثيقة |
: |
مقال في مجلة دورية |
|
عنوان الوثيقة |
: |
iPhos-PseEn: identifying phosphorylation sites in proteins by fusing different pseudo components into an ensemble classifier iPhos-PseEn: identifying phosphorylation sites in proteins by fusing different pseudo components into an ensemble classifier |
|
لغة الوثيقة |
: |
الانجليزية |
|
المستخلص |
: |
Protein phosphorylation is a posttranslational modification (PTM or PTLM),
where a phosphoryl group is added to the residue(s) of a protein molecule. The
most commonly phosphorylated amino acids occur at serine (S), threonine (T), and
tyrosine (Y). Protein phosphorylation plays a significant role in a wide range of
cellular processes; meanwhile its dysregulation is also involved with many diseases.
Therefore, from the angles of both basic research and drug development, we are
facing a challenging problem: for an uncharacterized protein sequence containing
many residues of S, T, or Y, which ones can be phosphorylated, and which ones
cannot? To address this problem, we have developed a predictor called iPhos-PseEn
by fusing four different pseudo component approaches (amino acids’ disorder scores,
nearest neighbor scores, occurrence frequencies, and position weights) into an
ensemble classifier via a voting system. Rigorous cross-validations indicated that
the proposed predictor remarkably outperformed its existing counterparts. For the
convenience of most experimental scientists, a user-friendly web-server for iPhos-
PseEn has been established at http://www.jci-bioinfo.cn/iPhos-PseEn, by which
users can easily obtain their desired results without the need to go through the
complicated mathematical equations involved. |
|
ردمد |
: |
2732-3404 |
|
اسم الدورية |
: |
Oncotarget |
|
المجلد |
: |
7 |
|
العدد |
: |
32 |
|
سنة النشر |
: |
1437 هـ
2016 م |
|
نوع المقالة |
: |
مقالة علمية |
|
تاريخ الاضافة على الموقع |
: |
Wednesday, July 12, 2017 |
|
الباحثون
| Wang-Ren Qiu | Qiu, Wang-Ren | باحث | دكتوراه | |
| Xuan Xiao | Xiao, Xuan | باحث | دكتوراه | |
| Zhao-Chun Xu | Xu, Zhao-Chun | باحث | دكتوراه | |
| Kuo-Chen Chou | Chou, Kuo-Chen | باحث | دكتوراه | |
|