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نوع الوثيقة : مقال في مجلة دورية 
عنوان الوثيقة :
Vascular endothelial growth factor (VEGFA) gene variation in polycystic ovary syndrome in a Tunisian women population.
Vascular endothelial growth factor (VEGFA) gene variation in polycystic ovary syndrome in a Tunisian women population.
 
لغة الوثيقة : الانجليزية 
المستخلص : Background: Polycystic ovary syndrome (PCOS) is characterized by the growth of a number of small cysts on the ovaries which leads to sex hormonal imbalance. Women who are affected by this syndrome suffer from irregular menstrual cycles, decline in their fertility, excessive hair growth, obesity, acne and most importantly cardiac function problems. The vascular endothelial growth factor (VEGF) plays a pivotal role in tissue vascularization in general and in the pathogenesis of many diseases. The PCOS was found to be associated with high expression levels of VEGF. In women who undergo assisted reproductive procedures (ART), VEGF was found to be a key mediator of other factors to control ovary angiogenesis. Here, we set out to examine the association of VEGFA gene polymorphism with PCOS and its components in a population of Tunisia women to enhance our understanding of the genetic background leading angiogenesis and vascularization abnormalities in PCOS. Methods: The association of VEGFA gene with PCOS and its components was examined in a cohort of 268 women from Tunisia involving 118 PCOS patients and 150 controls. VEGFA gene variations were assessed through the analysis of the following SNPs rs699947 (A/C), rs833061 (C/T), rs1570360 (G/A), rs833068 (G/A), rs3025020 (C/T), and rs3025039 (C/T). The linkage disequilibrium between SNPs was assessed using HAPLOVIEW software while combination of SNPs into haplotypes in the population and the reconstruction of the cladogram were carried-out by PHASE and ARLEQUIN programs, respectively. Genetic association and genotype-phenotype correlations were calculated by logistic regression and non-parametric tests (Kruskall-Wallis and Mann–Whitney tests), respectively, using StatView program. Results: We observed 10 haplotypes in our studied cohort whereH1 (ACGG), H2 (ACAG), H7 (CTGG) and H8 (CTGA) were the most frequent. We observed the association of the genotype CT of the SNP rs30225039 with PCOS phenotype (P = 0.03; OR 95 % CI = 2.05 [1.07–3.90]) and a trend for correlation of the pair of haplotypes H2/H2 with prolactin levels in plasma (P = 0.077; 193.5 ± 94.3 vs 45.7 ± 7.2). These data are consistent with literature and highlight one more time the role of vascularization in the pathogeny of PCOS. (Continued on next page) 
ردمد : 1471-2164 
اسم الدورية : BMC genomics 
المجلد : 17 
العدد : 9 
سنة النشر : 1437 هـ
2016 م 
نوع المقالة : مقالة علمية 
تاريخ الاضافة على الموقع : Monday, July 17, 2017 

الباحثون

اسم الباحث (عربي)اسم الباحث (انجليزي)نوع الباحثالمرتبة العلميةالبريد الالكتروني
Assila Ben SalemBen Salem, Assila باحثدكتوراه 
Fatma MegdichMegdich, Fatma باحثدكتوراه 
Olfa KacemKacem, Olfa باحثدكتوراه 
Malek SouayehSouayeh, Malek باحثدكتوراه 
Faten Hachani Ben AliBen Ali, Faten Hachaniباحثدكتوراه 
Sondes HizemHizem, Sondes باحثدكتوراه 
Faouzi JanhaiJanhai, Faouzi باحثدكتوراه 
Mounir AjinaAjina, Mounir باحثدكتوراه 
Muhammad Abu-ElmagdAbu-Elmagd, Muhammad باحثدكتوراه 
Mourad AssidiAssidi, Mourad باحثدكتوراه 
Mohammed H. Al QahtaniAl Qahtani, Mohammed H.باحثدكتوراه 
Touhami MahjoubMahjoub, Touhami باحثدكتوراه 

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