تفاصيل الوثيقة

نوع الوثيقة : مقال في مجلة دورية 
عنوان الوثيقة :
Human sex hormone-binding globulin as a potential target of alternate plasticizers: an in silico study
Human sex hormone-binding globulin as a potential target of alternate plasticizers: an in silico study
 
لغة الوثيقة : الانجليزية 
المستخلص : Background: Currently, alternate plasticizers are used to replace phthalate plasticizers in children’s toys, medical equipments and food packaging, due to the adverse effects of phthalate compounds on human health and laws prohibiting their use. Current information regarding the safety and potential adverse effects of alternate plasticizers is limited and recent studies have found alternate plasticizers to display similar characteristics to those observed in phthalate plasticizers. This study was undertaken to evaluate and predict the potential endocrine disrupting activity of the three most commonly used alternate plasticizers: di(2-ethylhexyl)terephthalate (DEHT), tris(2-ethylhexyl) trimellitate (TOTM), and diisononyl hexahydrophthalate (DINCH) against human sex hormone-binding globulin (SHBG) using in silico approaches. Materials and methods: The crystal structure of human SHBG (Id: 1D2S) was retrieved from Protein Data Bank. PubChem database was searched for the structures of alternate plasticizers, DEHT, TOTM, and DINCH. Docking was performed using Glide (Schrodinger) Induced Fit Docking module. Results: Induced Fit Docking of three alternate plasticizer compounds indicated that each of the three compounds fitted well into the steroid binding pocket of SHBG. Docking displays showed interactions of alternate plasticizers with 25–30 amino-acid residues of SHBG; 18–20 amino residues overlapped between the natural ligand, DHT, and the three compounds (commonality of 82–91 %). The hydrogen-bonding interaction of the amino-acid residue, Asn-82, of SHBG was also present in displays of DHT and all the three alternate phthalates. The binding affinity of all the three alternate phthalates was higher than DHT; maximum in DINCH followed by TOTM and DEHT. Conclusion: Our results suggested that the three alternate plasticizers have potential to engage the important interacting residues of SHBG and thus interfere in its steroid homeostatic function. 
ردمد : 1472-6807 
اسم الدورية : BMC structural biology 
المجلد : 16 
العدد : 1 
سنة النشر : 1437 هـ
2016 م 
نوع المقالة : مقالة علمية 
تاريخ الاضافة على الموقع : Tuesday, July 18, 2017 

الباحثون

اسم الباحث (عربي)اسم الباحث (انجليزي)نوع الباحثالمرتبة العلميةالبريد الالكتروني
Ishfaq A SheikhSheikh, Ishfaq Aباحثدكتوراه 
Muhammad YasirYasir, Muhammad باحثدكتوراه 
Muhammad Abu-ElmagdAbu-Elmagd, Muhammad باحثدكتوراه 
Tanveer A DarDar, Tanveer Aباحثدكتوراه 
Adel M AbuzenadahAbuzenadah, Adel Mباحثدكتوراه 
Ghazi A DamanhouriDamanhouri, Ghazi Aباحثدكتوراه 
Mohammed Al-QahtaniAl-Qahtani, Mohammed باحثدكتوراه 
Mohd A. BegBeg, Mohd A.باحثدكتوراه 

الملفات

اسم الملفالنوعالوصف
 42093.pdf pdf 

الرجوع إلى صفحة الأبحاث