تفاصيل الوثيقة

نوع الوثيقة : مقال في مجلة دورية 
عنوان الوثيقة :
Identification of novel genetic variations affecting osteoarthritis patients
Identification of novel genetic variations affecting osteoarthritis patients
 
لغة الوثيقة : الانجليزية 
المستخلص : Background: Osteoarthritis (OA) is a progressive joint disease characterized by gradual degradation of extracellular matrix (ECM) components in the cartilage and bone. The ECM of cartilage is a highly specified structure that is mainly composed of type II collagen and provides tensile strength to the tissue via aggrecan and proteoglycans. However, changes in the ECM composition and structure can lead to loss of collagen type II and network integrity. Several risk factors have been correlated with OA including age, genetic predisposition, hereditary factors, obesity, mechanical injuries, and joint trauma. Certain genetic association studies have identified several genes associated with OA using genome-wide association studies (GWASs). Results: We identified several novel genetic variants affecting genes that function in several candidate causative pathways including immune responses, inflammatory and cartilage degradation such as SELP, SPN, and COL6A6. Conclusions: The approach of whole-exome sequencing can be a promising method to identify genetic mutations that can influence the OA disease. 
ردمد : 1471-2350 
اسم الدورية : BMC medical genetics 
المجلد : 17 
العدد : 1 
سنة النشر : 1437 هـ
2016 م 
نوع المقالة : مقالة علمية 
تاريخ الاضافة على الموقع : Tuesday, July 18, 2017 

الباحثون

اسم الباحث (عربي)اسم الباحث (انجليزي)نوع الباحثالمرتبة العلميةالبريد الالكتروني
Mamdooh Abdullah GariGari, Mamdooh Abdullahباحثدكتوراه 
Mohammed AlKaffAlKaff, Mohammed باحثدكتوراه 
Mohammed M AbbasAbbas, Mohammed Mباحثدكتوراه 
Haneen S AlsehliAlsehli, Haneen Sباحثدكتوراه 
Ashraf DallolDallol, Ashraf باحثدكتوراه 
Abdullah GariGari, Abdullah باحثدكتوراه 
Muhammad Abu-ElmagdAbu-Elmagd, Muhammad باحثدكتوراه 
Roaa KadamKadam, Roaa باحث  
Mohammed F. AbuzinadahAbuzinadah, Mohammed F.باحثدكتوراه 
Mazin GariGari, Mazin باحثدكتوراه 
Adel M AbuzenadahAbuzenadah, Adel Mباحثدكتوراه 
Kalamegam GauthamanGauthaman, Kalamegam باحثدكتوراه 
Heba AlkhatabiAlkhatabi, Heba باحثدكتوراه 

الملفات

اسم الملفالنوعالوصف
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