Document Details

Document Type : Thesis 
Document Title :
Utility of different analytical methods for the microdeterminationof some recent antibiotics.
استخدام طرق تحليلية مختلفة للتقدير الكمي الدقيق لبعض المضادات الحيوية الحديثة
 
Subject : Antibiotics 
Document Language : Arabic 
Abstract : The medication pharmaceutical is a hope and safety for all patients who have their health deteriorates. Therefore, the quality of the product is vital and necessary for the life of human being as well as ensuring the effectiveness of the product, in warm places. Given the importance of pharmaceutical treatments between patients and concentrations seized during the treatment, it is wise to tighten quality control on these pharmaceuticals available in the market, whether domestic or imported.Thus, the development of new simple and inexpensive spectrophotometric methods. In this work, three flouroquinolones drugs (gemifloxacine, gatifloxacine, and pefloxacine) and one of antihistamine drug (meclizin) were determined by three simple and sensitive spectrophotometric methods. The first method was based on the reaction of these drugs with bromophenol blue (BPB) in the presence of acetate buffer solution to give a highly coloured ion pair complexes, extractable with chloroform. The second method was based on oxidation of the drugs by potassium permanganate in acidic medium and determined the unreacted oxidant by measuring the decrease in absorbance by methylene blue (MB). The finally method was based on the reaction of the drugs with ninhydrin reagent in the presence of different organic solvents. The proposed methods are applied for determination of the studied drugs in their tablet formulations and spiked human urine and plasma. The results were in good agreement with those obtained by the official and HPLC methods. 
Supervisor : Alaa S. AmIN 
Thesis Type : Master Thesis 
Publishing Year : 1432 AH
2011 AD 
Number Of Pages : 139 
Added Date : Wednesday, August 28, 2013 

Researchers

Researcher Name (Arabic)Researcher Name (English)Researcher TypeDr GradeEmail
زكية ضيف الله الملاحAl-Mallah, Zakiya Dhaif-AllahInvestigatorMaster 

Files

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 35860.doc doc 
 35861.doc doc 
 35862.doc doc 
 35863.doc doc 
 35864.doc doc 

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